Aim is to study and compare the anti-nociceptive activity of extract of T. terrestris in LPS induced inflammation in
RAW264.7 macrophages. In in vitro, alkaloid enriched fraction of T. terrestris, showed significant increase in cell
viability in LPS induced inflammatory model

Alzheimer’s disease, known to be associated with the gradual loss of memory, is characterized by low concentration
of AChE in hippocampus and cortex part of the brain. We have studied inhibition kinetics and pharmacological
profiles with insilico tools such as molecular docking. Q site finder was used to locate the active site for binding of
ligand on the selected protein (1B41 and 2PM8). Molecular docking studies revealed that the potential of plant
phytoconstituents of Bacopa Monniera and Withania Somnifera to inhibit ChE’S was attributable to cumulative
effects of strong H2-bonds,cationin-π,π-π interactions and hydrophobic interactions.

The objective of the present study is to identify selected medicinal plants (Emblica officinalis,
Withaniasomnifera&Zingiberofficinale) which possess anticancer activity according to their traditional claims. The
phytoconstituents in the plant, Withaniasomnifera and Emblica officinale showed good binding affinity towards
thymidylate synthase and p-glycoprotein respectively as compared to that of the standards. From the results of MTT
analysis, it can be concluded that Zingiber officinalis was found to inhibit HT-29 cell lines to a greater extent Almost
all the extracts were found to produce an excellent anticancer activity. The activity can be attributed either to the
expression of the molecular targets having a maximal affinity to the chemical constituents present in these plants or
might also be due to the higher penetration power of the active principles which might have resulted in cell
inhibitions.

Aim is to study DNA methyl transferase inhibitory activity of cucurbitacin to treat prostate cancer by using PC cell
lines. evaluation of cytotoxity of CuE in prostate cancer cell lines LNCaP (AR +ve) and PC3 (AR -ve) reveals that CuE
is more selective toward AR negative cell line (PC3) than AR positive cell line (LNCaP).
Key Words: cucurbitacin, DNA methyl transferase inhibitory

Aim of the study is to investigate phytic acid for antidiabetic activity using in vivo and in vitro models. The decreased
body weight in diabetic rats is due to excessive breakdown of tissue protein. Treatment with phytic acid or
glimepiride improved body weight significantly inducing prevention of muscle wasting due to hyperglycemic
condition. Administration of phytic acid to diabetic rats reduced the glycosylation of haemoglobin by virtue of its
normo glycemic activity and thus decreases the level of glycosylated A1c in diabetic rats.
Key Words: phytic acid, antidiabetic activity

The present study has evaluated the antiepileptic activity of hydroalcoholic extracts of E.stricta (HAEES) bark
against MES, PTX and PTZ – induced epileptic seizures in rats. The HAEES was significantly antagonized PTX and
PTZ induced epileptic clonic seizures. However, it did not affect the extensor and tonic phase seizures induced by
MES, but significantly inhibit clonic seizures. Both PTX and PTZ are GABA-ergic blockers, by selective blocker of
the chloride ionophore complex to the GABAA receptor. Therefore the mechanism of antiepileptic effect of HAEES
may due to enhancing GABA receptor and blocking multineuronal pathways in the spinal cord.

The present study was aimed to investigate anti-oxidant and anti-microbial activities of root(s) of Punica granatum
hydroalcoholic extract in DPPH method and cup plate and disc diffusion method respectively. The extract was GCMS
for the confirmation of active phytoingredients responsible for the desired biological response. Both the studies
showed the presence of various compounds like quercetin, polyphenols, propanethiol etc. The anti-microbial activity
done by cup plate and disc diffusion method showed broad spectrum antimicrobial activity by acting on both gram
positive and gram negative pathogens, which was compared with ciprofloxacin.

Aim of the study is to carry out in Vitro Antioxidant Activity of Glinus Oppositifolius, Erythrina Stricta AndTrigonella Foenum – Graecum. Very good activity of ethanolic extract of Glinus oppositifolius, Erythrina stricta andTrigonella foenum-graecum is probably due to the presence of substance with an available hydroxyl groups. Thereducing capacity of a compound may serve as a significant indicator of its potential antioxidant activity.Key Words: Antioxidant Activity, Glinus Oppositifolius, Erythrina Stricta, Trigonella Foenum

Synthesized compounds were characterized, screened for their anticancer, antimycobacterial, antibacterial andantifungal activities. It was found that pyramidins 1c and 2a, 4a and 6abd, and 10d, 11a and 12d exhibited excellentanticancer activity against Ehrlich ascites carcinoma. In case of antimycobacterial activity 2ac and 3cdf and 4b, 6b and8c exhibited potent antimycobacterial activity.Key Words: pyramidins , anticancer activity

Synthesis of Quinozoline 2,4 (1H,3H) dione was done and characterized by IR, NMR and mass. The results of antitubercularactivity revealed that title compounds 7a-e and 8a-c exhibited significant activity. These compounds haveamido, thioamido, imidamido, N,Ndimethyl guanidinyl and N-pyridoyl moieties at 3 rd position of quinazolinone ring.The study revealed the necessity of synthesizing many more compounds having these moieties.Key Words: Quinozoline 2,4 (1H,3H) dione, anti-tubercular activity